Draetta, G., Brizuela, L., Potashkin, J. and Beach, D. 1987. Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2 and suc1. Cell 50, 319-325.

Brizuela, L. , Draetta, G. and Beach, D. 1987. p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J. 6 (11), 3507-3514.

Dunphy, W., Brizuela, L., Beach, D. and Newport, J. 1988. Xenopus cdc2 protein kinase is a component of MPF. Cell 54, 423-431.

Draetta, G., Brizuela, L. and Beach, D. 1988. p34 protein kinase, a human homolog of the yeast cell cycle control proteins encoded by cdc2 and cdc28. In Cancer Cells 6. T. Kelli and B. Stillman (eds). CSHL, Cold Spring Harbor, NY.

Brizuela, L., Draetta, G. and Beach, D. 1988. Physical association between the products of cdc2 and suc1 genes of fission yeast and their homologs in mammalian cells. In Nuclear Oncogenes. E. Harlow (ed.). CSHL, Cold Spring Harbor, NY.

Arion, D., Meijer, L., Brizuela, L. and Beach, D. 1988. cdc2 homolog is a subunit of the M phase-specific histone H1 kinase of starfish meiotic oocytes. Cell 55, 371-378.

Draetta, G., Luca, F., Westendorf, J., Brizuela, L., Ruderman, J. and Beach, D. 1988. Interaction of the cdc2 kinase with cyclins. Cell 56, 829-838.

Draetta G., Brizuela L., Beach D. 1988. p34, a protein kinase involved in cell cycle regulation in eukaryotic cells. Adv Exp Med Biol 231:453-457.

Brizuela, L. , Draetta, G. and Beach, D. 1989. Activation of cdc2 as a histone H1 kinase is associated with complex formation with the p62 subunit. PNAS 86, 4362-4366.

Riabowol, K., Draetta, G., Brizuela, L., Vandre, L. and Beach, D. 1989. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell 57, 394-401.

Meijer, L., Arion, D., Goldsteyn, R., Pines, J., Brizuela, L., Hunt, T. and Beach, D. 1989. Cyclin is a subunit of the sea urchin M-phase specific histone H1 kinase. EMBO J. 6 (11), 3507-3514.

Mc Vey, D., Brizuela, L., Mohr, I, Marshak, D., Gluzman, Y. and Beach, D. 1990. Phosphorylation of T antigen by cdc2 stimulates SV40 DNA replication. Nature 341, 503-507

Luscher, B., Brizuela, L., Beach, D. and Eisenman. R. 1991. A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle. EMBO 10 (4), 865-876.

Weiderrecht, G., Brizuela, L., Elliston, K., Nolan, S. and Siekierka, J. 1991. FKB1 encodes a nonessential FK506-binding protein in S. cerevisiae and contains a region suggesting homology to the cyclophilins.PNAS 88, 1029-1033.

Brizuela, L., Chrebet, G., Bostian, K. and Parents, S. 1991. Antifungal propierties of the immunosuppressor FK-506: Identification of an FK-506 responsive yeast gene distinct from FKB1. MCB 11 (9), 4616-4626.

Neilsen, J., Foor, F, Siekierka, J., Hsu, M., Ramadan, N., Morin, N., Shafiee, A., Dhal, A., Brizuela, L. , Chrebet, G , Bostian, K. and Parents, S. 1992. The yeast FKBP-13 is membrane associated FK506-binding protein encoded by the nonessential gene FKB2. PNAS 89, 7471-75.

Sigal, N., Dumont, F., Siekierka, J., Wiederrecht, G., Parents, S. and Brizuela, L. 1992. Is FKBP involved in the immunosuppresive and/or toxic mechanism of action of FK506 ?. Transplant. Proc. 23, 2846-2849.

Brizuela, L., Ulug, T., Jones, M. and Courtneidge, S. 1995. Induction of Il2 transcription by the hamster polyomavirusmiddle T antigen : a role for Fyn in T cell signal transduction. Eur. J. Immunol. 25, 385-393.

Wick, S., Dubay, M., Imanil, I. and Brizuela, L. 1995. Biochemical and mutagenic analysis of the melanoma tumor suppressor gene product/p16. Oncogene: 11, 2013-2019.

Carlson, B.A., Dubay, M.M., Sausville, E.A., Brizuela, L. and Worland, P.J. 1996. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (cdk) 2 and cdk4 in human breast carcinoma cells. Cancer Res.: 56, 2973-2978.

Lamphere, L., Fiore, F., Keezer, S., Brizuela, L., Draetta, G and Gyuris, J. 1997. Interaction between Cdc37 and Cdk4 in human cells. Oncogene: 14, 1999-2004.

Luh, F. Y., Archer, S. J., Domaille, P. J., Smith, B. O., Owen, D., Brotherton, D. H., Raine, A. R.C., Xu, X., Brizuela L.?, Brenner S. and Laue E. D. 1997. Structure of the Cyclin Dependent Kinase Inhibitor p19^INK4d. Nature: 389, 999-1002.

Brotherton D.H., Dhanaraj V., Wick S., Brizuela L., Domaille P.J., Volyanik E., Xu X., Parisini E., Smith B.O., Archer S.J., Serrano M., Brenner S.L., Blundell T.L., Laue E.D. 1998. Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the
cell-cycle inhibitor p19INK4d. Nature: 395, 244-50

Xu,X., Nakano, T., Wick, S. Dubay, M. and Brizuela, L. 1999. Mechanism of CDK2/cyclin E inhibition by p27 and p27 phosphorylation. Biochemistry 38, 8713-22

Brizuela, L., Gyuris, J. and Mansuri, M. 2000. Cyclin Dependent Kinases and their Regulators as Potential Targets for Anticancer Therapeutics. In Principles of Molecular Oncology. Bronchud, M (ed). Human Press Inc. NJ.

Murthy, K., Dubay, M., McClure, C., Brizuela, L., Boisclair, M., Worland, P., Manzuri, M. and Pall, K. 2000. Cyclin dependent Kinase inhibitory activity of Flavopiridol analogs. Bioorg. & Medic. Chem. Lett. 10:1037-1041

Strack, P., Caliguri M., Pelletier, M., Boisclair, M., Theodoras, A., Beer-Romero, P., Glass, S., Parsons, T., Copeland, R.A., Auger, K., Bendfield, P., Brizuela, L. and Rolfe, M. 2000. SCF?TRCP and phosphorylation dpendent ubiquitination of IkB??is catalyzed by Ubc3 and Ubc4. Oncogene. 19: 3529-3536.

Brizuela, L., Braun, P. And Labaer, J. 2001. FLEXGene repository: from sequenced genomes to gene repositories for high-throughput functional biology and proteomics. Mol. Bioch. Parasit 118:155-65.

Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM. 2001. Identification of selective inhibitors of cyclin dependent kinase 4. Bioorg Med Chem Lett 11:2209-11

Brizuela, L., Richardson, A., Marsischky, G and LaBaer, J. 2002. Exploiting the fruits of the genome sequencing projects by creating a needed resource to face the challenges of the post-genomic era. Arch. Med. Res.33:318-324.